مدل ریاضی چند هدفه برای مساله تولید-موجودی-مسیریابی دو مرحله‌ای محصولات دارویی

نوع مقاله : مقاله پژوهشی

نویسندگان

1 کارشناس ارشد مهندسی صنایع، گروه مهندسی صنایع، دانشگاه سمنان، سمنان، ایران

2 دانشیار، گروه مهندسی صنایع، دانشگاه سمنان، سمنان، ایران

چکیده

زنجیره تأمین دارو بخشی از سیستم سلامت است که اهمیت بسزایی در افزایش سلامت جامعه دارد و از این رو یک مساله حیاتی و اساسی در هر کشوری است. در این مقاله سعی شده است با بررسی مساله یکپارچه تولید-موجودی-مسیریابی با یکی از مهم‌ترین چالش‌های حال حاضر صنعت دارو، یعنی عدم هماهنگی بین بخش‌های مختلف زنجیره، مقابله شود. مساله مورد بررسی دارای دو تابع هدف است که تابع هدف اول آن کمینه‌سازی هزینه‌های کل سیستم شامل هزینه‌های ثابت و متغیر تولید، انتقال دارو بین سطوح مختلف، نگهداری و فساد محصولات و تابع هدف دوم کمینه‌سازی تاثیرات زیست محیطی ناشی از تولید و انتقال داروها می‌باشد. بعلاوه در این مساله، حالت تولید توسط چند تولیدکننده مختلف و توزیع دومرحله‌ای نیز در نظر گرفته شده‌اند. ‌پس از ارایه مدل ریاضی مساله مذکور، به منظور مقابله با تغییرات تقاضا از رویکرد تصادفی سناریو محور به منظور مدلسازی استفاده می‌شود. همچنین مدل مذکور در شرکت داروسازی بایرپل فناور پیاده‌سازی و نتایج تحلیل و بررسی می‌شود. نتایج نشان داد که افزایش تقاضا موجب افزایش هر دو تابع هدف مساله می‌شود. در انتها نیز روی دو پارامتر مساله تحلیل حساسیت انجام می‌شود. همچنین افزایش هزینه های راه اندازی موجب افزایش تابع هدف هزینه و کاهش تابع هدف انتشار گازهای گلخانه‌ای می‌شود.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

A Multi Objective Mathematical Model for Two-Echelon Production-Inventory-Routing Problem of Pharmaceutical Products

نویسندگان [English]

  • Narjes Salmabadi 1
  • Mohammad Ali Beheshtinia 2
1 MSc. Grad., Department of Industrial Engineering, Semnan University, Semnan, Iran
2 Associate Professor, Department of Industrial Engineering, Semnan University, Semnan, Iran
چکیده [English]

The drug supply chain is a part of the health care system, which is of great importance in increasing the health of the community and therefore it is a critical issue in any country. In this paper, we have tried to deal with one of the most important challenges of the current pharmaceutical industry, namely the lack of coordination between different sectors of the chain, by presenting a mathematical model for integrated production-inventory-routing problem. The problem has two objective functions; the first objective function minimizes the total cost of the system, including fixed and variable costs of production, transportation, inventory and spoilage cost, and the second objective function minimizes environmental impacts caused by the production and transportation of drugs. In addition, in this paper, the production mode by several different manufacturers and two-stage distribution is considered. After presenting the mathematical model of the above problem, in order to cope with demand uncertainty, a scenario-based stochastic programming is used for modeling. The model will be implemented at BayerPool Pharmaceutical Company and the results will be analyzed. The results showed that increasing demand led to increases in both objective functions of the problem. At the end, sensitivity analysis is also done on two parameters of the problem. Increasing setup costs of production increases the total cost objective function and reduces the greenhouse gas emissions objective function.

کلیدواژه‌ها [English]

  • Supply chain
  • transportation
  • stochastic programming
  • two echelon vehicle routing problem and production-routing problem
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